As the Arizona Cardinals prepare for their Week 6 matchup against the Indianapolis Colts, all eyes are on quarterback Kyler Murray. Listed as “questionable” due to a foot injury sustained in the previous game, Murray’s status has been a topic of intense speculation. With kickoff approaching, the question remains: Will Kyler Murray be playing today, playing tomorrow, out, or serving as a backup?
Injury Overview
Kyler Murray suffered a mid-foot sprain during the Cardinals’ narrow 22-21 loss to the Tennessee Titans in Week 5. The injury occurred when Murray was unexpectedly hit in the face with a snap, leading to a fumble and a subsequent brief exit from the game. Despite the setback, he returned to finish the game.
In the days following the game, Murray missed practice on Wednesday and Thursday but returned on Friday as a limited participant. Despite this progress, the Cardinals officially listed him as “questionable” for the Week 6 game against the Colts.
Official Status: Out
As of Sunday morning, October 12, 2025, Kyler Murray has been officially ruled out for the game against the Indianapolis Colts. The Cardinals have confirmed that Murray will not play due to the foot injury.
Backup: Jacoby Brissett
With Murray sidelined, veteran quarterback Jacoby Brissett is set to start for the Cardinals. Brissett, who previously played for the Colts from 2017 to 2020, will now face his former team for the first time as a Cardinal. Brissett brings significant experience to the role, having started 53 games in his NFL career.
In preparation for the game, Brissett has taken the majority of first-team practice reps, ensuring he is ready to lead the offense in Murray’s absence.
Roster Adjustments
In addition to elevating Brissett to the starting role, the Cardinals have made other roster adjustments to accommodate the quarterback change. Kedon Slovis has been elevated from the practice squad to the active roster, serving as the backup quarterback for the game.
These moves reflect the team’s efforts to ensure depth and readiness at the quarterback position, given the uncertainty surrounding Murray’s availability.
Fantasy Football Implications
For fantasy football managers, the absence of Kyler Murray presents challenges. Murray has been a dual-threat quarterback this season, contributing both in the air and on the ground. With Brissett starting, the offensive dynamic may shift, potentially affecting the fantasy value of key players like wide receiver Trey McBride and running back James Conner.
Brissett’s more conservative, less mobile playing style compared to Murray could lead to fewer opportunities for big plays, impacting the overall fantasy output of the offense.
Looking Ahead
Kyler Murray’s mid-foot sprain is being evaluated as a version of a Lisfranc injury, which could sideline him for more than one week. The Cardinals will continue to monitor his recovery, and updates on his status for future games will be provided as more information becomes available.
For now, the focus shifts to Jacoby Brissett and the rest of the team as they prepare to face the 4-1 Indianapolis Colts. Kickoff is scheduled for later today, and fans will be watching closely to see how the offense performs without its starting quarterback.
Conclusion
As of now, Kyler Murray is out for today’s game against the Indianapolis Colts due to a foot injury. Veteran quarterback Jacoby Brissett will start in his place, with Kedon Slovis serving as the backup. The team has made necessary roster adjustments to ensure depth at the quarterback position. Fantasy football managers should be aware of the potential impact on player performances due to the change in quarterback. Updates on Murray’s recovery and future availability will be provided as more information becomes available.
