The NFL schedule this week features the second week of the 2026 regular season, with a full slate of games beginning with Thursday Night Football and continuing through Monday Night Football. The Week 2 schedule includes several important matchups, including Detroit Lions vs. Buffalo Bills, Washington Commanders vs. Dallas Cowboys, Indianapolis Colts vs. Kansas City Chiefs, and New York Giants vs. Los Angeles Rams.
NFL Schedule This Week: Week 2
The action begins Thursday, Sept. 17, when the Detroit Lions travel to face the Buffalo Bills at 8:15 p.m. ET. The game will be shown on Prime Video, with mobile streaming also available through NFL+.
Sunday brings a packed schedule. The early window includes Panthers vs. Falcons, Saints vs. Ravens, Vikings vs. Bears, Bengals vs. Texans, Steelers vs. Patriots, Packers vs. Jets, Browns vs. Buccaneers and Eagles vs. Titans.
The afternoon schedule features Jaguars vs. Broncos, Raiders vs. Chargers, Seahawks vs. Cardinals, Commanders vs. Cowboys and Dolphins vs. 49ers. Sunday Night Football then closes the day with the Colts visiting the Chiefs.
Monday Night Football finishes Week 2 with the New York Giants visiting the Los Angeles Rams at 8:15 p.m. ET on ESPN, ESPN Deportes and ABC, with mobile streaming available through NFL+.
Lions vs. Bills Headlines Week 2
The first Thursday Night Football game of the season pits two teams that opened the campaign with 1-0 records. Detroit survived an overtime thriller against New Orleans, while Buffalo defeated Houston in a close road game. The Lions-Bills matchup will also be the first regular-season game at Buffalo’s new Highmark Stadium.
The matchup features prominent offensive players on both sides, including Jared Goff and Jahmyr Gibbs for Detroit and Josh Allen and James Cook for Buffalo. The game is scheduled for 8:15 p.m. ET on Prime Video.
Commanders vs. Cowboys
The Washington Commanders vs. Dallas Cowboys matchup is one of Sunday’s notable NFC East games. Both teams enter the contest at 0-1, creating an early opportunity to get their first victory of the season.
Jayden Daniels and Dak Prescott each threw two touchdown passes in their Week 1 games, according to the NFL’s Week 2 preview.
Colts vs. Chiefs
Sunday Night Football brings the Indianapolis Colts vs. Kansas City Chiefs matchup at 8:20 p.m. ET. The game will air on NBC and is also available for mobile streaming through NFL+.
Giants vs. Rams
Week 2 concludes with New York Giants vs. Los Angeles Rams on Monday night. The Giants enter after defeating Dallas, while the Rams are looking to respond following their season-opening loss in Australia.
How to Watch the NFL This Week
NFL+ provides access to live local and primetime games on mobile devices, while NFL+ Premium adds NFL RedZone, NFL Pro and full and condensed game replays. Sunday afternoon games are available in local markets, with mobile streaming available through NFL+.
With Thursday Night Football, a busy Sunday slate and Monday Night Football still ahead, the NFL schedule this week gives fans a full Week 2 lineup to follow from start to finish.
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